HIV-1 reverse transcriptase inhibitory activity of Aerva lanata plant extracts
نویسندگان
چکیده
Background HIV-1 reverse transcriptase (HIV-1 RT) is an essential enzyme for the replication cycle of HIV. HIV-1 RT inhibitors have been extensively investigated for their antiHIV properties. However, emergence of HIV drug resistance and side effects are the main reasons for failure of anti-HIV therapy. The aim of the present study was to evaluate the HIV reverse transcriptase inhibitory activity of Aerva lanata plant extracts.
منابع مشابه
In Vitro Anti Tubercular Activity of Leaves of Aerva lanata L.
Aerva lanata is broadly utilized in urinary issues in Southern part of India as a source of Pashana bheda. A member of Amaranthaceae that is normally known as Gorakha ganja, it is usually located on mountains as weed. Many researches have been carried out to elicit the diuretic and anti-urolithic interest of this plant. It also has been verified for other pharmacological activities like anti-he...
متن کاملPhytochemical Screening and Thin Layer Chromatographic Studies of Aerva Lanata Root Extract
India being a rich and varied flora of medicinal plants since the Vedic period. The present study deals with the phytochemical screening and thin layer chromatographic studies of Aerva lanata root extract belonging to family Amaranthaceae. Phytochemical screening determination by some chemical tests and thin layer chromatographic study was carried out by using various solvent system of varying ...
متن کاملCOMPARISION OF DIURETIC ACTIVITY OF ETHANOLIC EXTRACT OF AERVA LANATA (Linn.) Juss. ex. Schult & AERVA TOMENTOSA Forsk. Family: AMARANTHACEAE
The diuretic activity of concentrated ethanolic extract of Aerva lanata (Linn) & Aerva tomentosa Forsk on healthy albino rats were studied with frusemide as reference drug. The urine output increased with concentrated ethanolic extract of Aerva lanata only. In this case the level of electrolytes in urine also increased. But the diuretic activity was mild as compared to frusemide.
متن کاملAerva lanata (Linn.) Juss. ex Schult. – An overview
Aerva lanata (Linn.) Juss. ex Schult. (Family-Amaranthaceae) is an important source of chemicals of immense medicinal and pharmaceutical importance such as O-acyl glycosides, β-sitosterol, daucosterol, syringic acid, vanillic acid, feruloyl tyramine, feruloyl homovanillylamine, narcissin and aervitrine which are effective as diuretic, anthelmintic, antidiabetic, expectorant and in the treatment...
متن کاملAnti-HIV-1 activities in extracts from some medicinal plants as assessed in an in vitro biochemical HIV-1 reverse transcriptase assay.
An in vitro HIV-1 reverse transcriptase (RT) assay was used for screening of anti-HIV activity of extracts obtained from some Kenyan medicinal plants. The assay utilises [3H]-methyl thymidine triphosphate (dTTP) as the enzyme substrate and polyadenylic acid.oligodeoxythymidylic acid [poly(rA).p(dT)(12-18)] as the template-primer dimmer. This assay was optimised and standardised with respect to ...
متن کامل